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Can I read Implication of Gut Microbiota in the Association Between Infant Antibiotic Exposure and Childhood Obesity and Adiposity Accumulation on EtoBox?
Implication of Gut Microbiota in the Association Between Infant Antibiotic Exposure and Childhood Obesity and Adiposity Accumulation by Ling-Wei Chen; Jia Xu; Shu E Soh; Izzuddin M. Aris; Mya-Thway Tint; Peter D. Gluckman; Kok Hian Tan; Lynette Pei-Chi Shek; Yap-Seng Chong; Fabian Yap; Keith M. Godfrey; Jack A. Gilbert; Neerja Karnani; Yung Seng Lee is a Medicine article available to read on EtoBox.
What is Implication of Gut Microbiota in the Association Between Infant Antibiotic Exposure and Childhood Obesity and Adiposity Accumulation about?
## Background: In animal studies early life antibiotic exposure causes metabolic abnormalities including obesity through microbiota disruption, but evidence from human studies is scarce. we examined involvement of gut microbiota in the associations between infant antibiotic exposure and childhood adiposity. ## Methods: Infant antibiotic exposure in the first year of life was ascertained using parental reports during interviewer-administered questionnaires. primary outcomes were childhood obesity [body mass index (bmi) z-score > 95th percentile] and adiposity [abdominal circumference (ac) and skinfold (triceps + subscapular (sst)) measurements] determined from ages 15-60 months. at age 24 months, when the gut microbiota are more stable, stool samples (n = 392) were collected for the gut microbiota profiling using co-abundancy networks. associations of antibiotic exposure with obesity and adiposity (n = 1016) were assessed using multiple logistic and linear mixed effects regressions. key bacteria associated with antibiotics exposure were identified by partial redundancy analysis and multivariate association with linear models. ## Results: Antibiotic exposure was reported in 38% of st
Who reads Implication of Gut Microbiota in the Association Between Infant Antibiotic Exposure and Childhood Obesity and Adiposity Accumulation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ling-Wei Chen; Jia Xu; Shu E Soh; Izzuddin M. Aris; Mya-Thway Tint; Peter D. Gluckman; Kok Hian Tan; Lynette Pei-Chi Shek; Yap-Seng Chong; Fabian Yap; Keith M. Godfrey; Jack A. Gilbert; Neerja Karnani; Yung Seng Lee
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1476-5497)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)