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Dietary Intake and Gene Variation Influence the Response of Plasma Lipids to Dietary Intervention by Dr. Philippa J. Talmud; Eric Boerwinkle; Chun-fang Xu; Matti J. Tikkanen; Pirjo Pietinen; Jussi K. Huttunen; Steve Humphries; Aravinda Chakravarti is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract We have examined whether variation at the apolipoprotein (apo) B, apo E, apo AII, and apo AI‐CIII‐AIV genes affected the relationship between dietary intake and serum lipid traits in individuals who had participated in dietary intervention from a basal high fat diet to a low fat diet followed by a return to their natural diet, the switchback. On both the basal and switchback diets where the variance of dietary intake was great, there was a significant correlation between P/S ratio and serum total, low‐density lipoprotein (LDL) cholesterol, and apo A1 levels. In addition dietary cholesterol (dchol) levels correlated significantly with serum apo A1 levels on the basal diet. Comparing the difference between basal and intervention (Δ1) and between switchback and intervention diets (Δ2), changes in dchol and P/S ratio correlated significantly with changes in serum total, high‐density lipo‐protein (HDL) and LDL cholesterol, and apo B levels. There was a significant correlation between monounsaturated fatty acid (MUFA) and apo A1 levels during both changes. Furthermore we have examined whether the relationship between variables was homogeneous among genotypes of candidate gene

Who reads Dietary Intake and Gene Variation Influence the Response of Plasma Lipids to Dietary Intervention?

Author

Dr. Philippa J. Talmud; Eric Boerwinkle; Chun-fang Xu; Matti J. Tikkanen; Pirjo Pietinen; Jussi K. Huttunen; Steve Humphries; Aravinda Chakravarti

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

1992

Language

EN

ISBN

9781370090402

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)