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Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae–Papilionaceae) by Silmara Aparecida Faggion; Alexandra Olimpio Siqueira Cunha; Helene Aparecida Fachim; Amanda Salomão Gavin; Wagner Ferreira dos Santos; Ana Maria Soares Pereira; Renê Oliveira Beleboni is a Medicine article available to read on EtoBox.
What is Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae–Papilionaceae) about?
Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine from the flowers of Erythrina mulungu and evaluated the action of these compounds against chemically induced seizures in rats. Our results showed that the administration of different doses of (+)-erythravine inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid at maximum of 80, 100, and 100%, respectively, whereas different doses of (+)-11-α-hydroxy-erythravine inhibited seizures at a maximum of 100% when induced by bicuculline, NMDA, and kainic acid, and, to a lesser extent, PTZ (60%). The analysis of mean latency to seizure onset of nonprotected animals, for specific doses of alkaloids, showed that (+)-erythravine increased latencies to seizures induced by bicuculline. Although (+)-erythravine exhibited very weak anticonvulsant action against seizur
Who reads Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-α-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae–Papilionaceae)?
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- Author
- Silmara Aparecida Faggion; Alexandra Olimpio Siqueira Cunha; Helene Aparecida Fachim; Amanda Salomão Gavin; Wagner Ferreira dos Santos; Ana Maria Soares Pereira; Renê Oliveira Beleboni
- Publisher
- Elsevier BV
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)