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Natural immunodominant and experimental autoimmune encephalomyelitis-protective determinants within the lewis rat Vβ8.2 sequence include CDR2 and framework 3 idiotopes by M. Vainiene; B. Celnik; A.A. Vandenbark; G.A. Hashim; H. Offner is a Neuroscience article available to read on EtoBox.

What is Natural immunodominant and experimental autoimmune encephalomyelitis-protective determinants within the lewis rat Vβ8.2 sequence include CDR2 and framework 3 idiotopes about?

The VpS.2-39-59 peptide has served as a prototypic natural regulatory idiotope in Lewis rats developing experimental autoimmune encephalomyelitis (EAE). The purpose of the present study was to determine if additional regulatory regions were contained within the VpS.2 sequence expressed by most encephalogenic T cells. A comprehensive strategy utilizing VpS + hybridomas, a recombinant (r) VpS.2 molecule, and overlapping synthetic VpS.2 peptides reconfirmed the natural recognition of the 39-59 idiotope, and revealed a second immunodominant and EAE-protective determinant residing within residues 71-90. Both the VpS.2-39-59 and VpS.2-71-90 peptides were immunogenic, and each was recognized after immunization of Lewis rats with VpS + cells or rVpS.2, indicating the preservation of these epitopes during the processing of the VpS.2 chain. Moreover, both epitopes were recognized naturally by T cells from rats developing or recovering from EAE that had never been purposefully immunized with VpS.2 peptides or rVPS.2. Of additional interest, the VpS.2-31-50 peptide was recognized by T cells from some rats immunized with complete Freund's adjuvant (CFA) alone. This peptide possessed mildly prot

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Author

M. Vainiene; B. Celnik; A.A. Vandenbark; G.A. Hashim; H. Offner

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)