Can I read Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single-dose study on EtoBox?

Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single-dose study by Dr. R. Pahwa; J. Marjama; D. McGuire; K. Lyons; F. Zwiebel; P. Silverstein; R. Ward; W. C. Koller is a Medicine article available to read on EtoBox.

What is Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single-dose study about?

## Abstract We compared the pharmacokinetic and motor responses of Sinemet and Atamet (generic carbidopa/levodopa) in patients with Parkinson's disease. Thirty Parkinson's disease patients (10 previously untreated, 10 with early disease, and 10 with motor fluctuations/dyskinesia) participated in a single‐dose double‐blind study. Following administration of an equivalent oral dose of Sinemet and Atamet on two separate days, we compared the peak plasma concentration, time to peak plasma concentration, area under the curve, total motor score, tapping score, and walking time. The mean time to peak plasma concentration was 49 min with Sinemet and 47 min with Atamet, the mean peak plasma concentration was 1,273 ng/ml with Sinemet and 1,153 ng/ml with Atamet, and the mean area under the curve was 2,295 m̈g/ml/h with Sinemet and 2,330 m̈g/ml/h with Atamet. Similarly, there was no significant difference between total motor score, tapping score, of walking time. In this single‐dose study, there were no significant differences in pharmacokinetic and motor responses between Sinmet and Atamet.

Who reads Pharmacokinetic comparison of sinemet and atamet (Generic carbidopa/levodopa): A single-dose study?

Author

Dr. R. Pahwa; J. Marjama; D. McGuire; K. Lyons; F. Zwiebel; P. Silverstein; R. Ward; W. C. Koller

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1996

Language

EN

Field

Medicine (Health Sciences)