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The placebo response rate and nocebo events in obesity pharmacological trials. A systematic review and meta-analysis by Yip Han Chin; Cheng Han Ng; Nicholas WS Chew; Gwyneth Kong; Wen Hui Lim; Darren Jun Hao Tan; Kai En Chan; Ansel Tang; Daniel Q Huang; Mark Y Chan; Gemma Figtree; Jiong-Wei Wang; Asim Shabbir; Chin Meng Khoo; Vincent Wai-Sun Wong; Dan Yock Young; Mohammad Shadab Siddiqui; Mazen Noureddin; Arun Sanyal; David E. Cummings; Nicholas Syn; Mark Dhinesh Muthiah is a Medicine article available to read on EtoBox.

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## Summary ## Background There is a growing number of trials examining the effectiveness of pharmacotherapies for obesity, however, little is known about placebo and nocebo effect in these trials. Hence, we sought to examine the effect of placebo in obesity trials, to better understand the potential factors affecting clinical endpoints in them. ## Methods Medline, Embase, and Cochrane CENTRAL were searched for articles examining weight-loss RCTs examining patients with overweight or obesity in placebo-controlled arms from inception till 25 June 2022. This paper was registered online with PROSPERO (CRD42022302482). A single arm meta-analysis of proportions was used to estimate the primary outcomes, ≥5%, ≥10%, and ≥15% total weight loss – and the adverse effects that patients experienced during the trial. A meta-analysis of means was used to estimate the pooled mean differences of the secondary outcomes including, body weight measurements, lipid levels, glycemic indices, and blood pressure over time. ## Findings A total of 63 papers involving 20,454 patients and 69 trials were included. The proportion of patients that had ≥5%, ≥10%, and ≥15% weight loss was 20·4% (CI:16·1% to 25·0%),

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Author

Yip Han Chin; Cheng Han Ng; Nicholas WS Chew; Gwyneth Kong; Wen Hui Lim; Darren Jun Hao Tan; Kai En Chan; Ansel Tang; Daniel Q Huang; Mark Y Chan; Gemma Figtree; Jiong-Wei Wang; Asim Shabbir; Chin Meng Khoo; Vincent Wai-Sun Wong; Dan Yock Young; Mohammad Shadab Siddiqui; Mazen Noureddin; Arun Sanyal; David E. Cummings; Nicholas Syn; Mark Dhinesh Muthiah

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)