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This document summarizes recent advances in understanding the regulation of the tricarboxylic acid (TCA) cycle. The TCA cycle is composed of eight enzymes that link the oxidation of pyruvate and malate to CO2 production with NADH generation. While the TCA cycle was described over 50 years ago, relatively little is known about how this important pathway is regulated. The review focuses on mitochondrial reactions and discusses regulation of TCA cycle enzymes from both historical kinetic studies and more recen

Author

Maximiliano Tapia Vazquez

Language

EN