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Premedication Practices for Less Invasive Surfactant Administration — Results from a Nationwide Cohort Study by Paweł Krajewski; Dawid Szpecht; Roman Hożejowski is a Medicine article available to read on EtoBox.

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## Background and aims: There are no established premedication schemes for less invasive surfactant administration (lisa) in neonatal rds. the aim was to describe "real-world" practices and to assess the safety of premedication and its impact on the technical ease of the lisa procedure. ## Methods: Data from the prospective lisa cohort study conducted in 31 tertiary neonatal units were evaluated for premedication practices. infants who received analgesics and/or sedatives before lisa and those receiving non-pharmacological sedation with sublingual 30% glucose were compared versus nonpremedicated neonates, acting as a reference. safety of premedication was assessed with the rate of adverse events during lisa, changes in oxygenation status, the need for rescue intubation, and mechanical ventilation in the first 24 h of life. ease of conducting lisa was an efficacy endpoint. ## Results: Of 500 enrolled newborns, 102 (20.4%) received premedication for lisa; 88 infants were given analgesics/sedatives and 14 sublingual glucose. pharmacological sedation was most often performed with ketamine (51/88; 57.9%), midazolam (16/88; 18.2%) and propofol (8/88; 1.6%). compared to non-premedication,

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Author

Paweł Krajewski; Dawid Szpecht; Roman Hożejowski

Publisher

Informa UK Limited

Published

2020

Language

EN

Field

Medicine (Health Sciences)