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Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung by Sanjay Gupta; Dinesh Doval; Kumar Prabhash; Shekar Patil; Harit Chaturvedi; Chanchal Goswami; Ashok Vaid; Saral Desai; Sarjana Dutt; Vidya Veldore; Nirmala Jambhekar; Anurag Mehta; Diganta Hazarika; Saud Azam; Sonal Gawande is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung about?
## Background Mutation in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) is a common feature observed in lung adenocarcinoma. A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the intracellular domain of anaplastic lymphoma kinase (ALK), named EML4-ALK, has been identified in a subset of non-small-cell lung cancer (NSCLC) tumors. The objective of this study was to determine the prevalence of EGFR mutations and EML4-ALK fusions in Indian patients with NSCLC (adenocarcinoma) as well as evaluate their clinical characteristics. ## Patients and methods Patients with NSCLC, adenocarcinoma histology, whose tumors had been tested for EGFR mutational status, were considered for this study. ALK gene rearrangement was detected by fluorescence in situ hybridization using the Vysis ALK Break Apart Rearrangement Probe Kit. ALK mutation was tested in samples that were negative for EGFR mutation. ## Results A total of 500 NSCLC adenocarcinoma patients were enrolled across six centers. There were 337 (67.4%) men and 163 (32.6%) women with a median age of 58 years. One hundred and sixty-four (32.8%) blocks were positive for EGFR mutations, where
Who reads Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sanjay Gupta; Dinesh Doval; Kumar Prabhash; Shekar Patil; Harit Chaturvedi; Chanchal Goswami; Ashok Vaid; Saral Desai; Sarjana Dutt; Vidya Veldore; Nirmala Jambhekar; Anurag Mehta; Diganta Hazarika; Saud Azam; Sonal Gawande
- Published
- 2015
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)