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TGFB1 Single Nucleotide Polymorphisms Are Associated With Adverse Quality of Life in Prostate Cancer Patients Treated With Radiotherapy by Christopher A. Peters; Richard G. Stock; Jamie A. Cesaretti; David P. Atencio; Sheila Peters; Ryan J. Burri; Nelson N. Stone; Harry Ostrer; Barry S. Rosenstein is a Medicine article available to read on EtoBox.
What is TGFB1 Single Nucleotide Polymorphisms Are Associated With Adverse Quality of Life in Prostate Cancer Patients Treated With Radiotherapy about?
## Purpose: To investigate whether the presence of single nucleotide polymorphisms (snps) located within tgfb1 might be predictive for the development of adverse quality-of-life outcomes in prostate cancer patients treated with radiotherapy. ## Methods and materials: A total of 141 prostate cancer patients treated with radiotherapy were screened for snps in tgfb1 using dna sequencing. three quality-of-life outcomes were investigated: (1) prospective decline in erectile function, (2) urinary quality of life, and (3) rectal bleeding. median follow-up was 51.3 months (range, 12-138 months; sd, 24.4 months). ## Results: Those patients who possessed either the t/t genotype at position -509, the c/c genotype at position 869 (pro/pro, codon 10) or the g/c genotype at position 915 (arg/pro, codon 25) were significantly associated with the development of a decline in erectile function compared with those who did not have these genotypes: 56% (9 of 16) vs. 24% (11 of 45) (p = 0.02). in addition, patients with the -509 t/t genotype had a significantly increased risk of developing late rectal bleeding compared with those who had either the c/t or c/c genotype at this position: 55% (6 of 11) vs
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- Author
- Christopher A. Peters; Richard G. Stock; Jamie A. Cesaretti; David P. Atencio; Sheila Peters; Ryan J. Burri; Nelson N. Stone; Harry Ostrer; Barry S. Rosenstein
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)