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Effects of maternal administration of vitamins C and E on ethanol neurobehavioral teratogenicity in the guinea pig by Christopher M. Nash; Ferda Ibram; Hans C. Dringenberg; James N. Reynolds; James F. Brien is a Medicine article available to read on EtoBox.

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Consumption of ethanol during human pregnancy can produce a wide spectrum of teratogenic effects, including neurobehavioral dysfunction. This study, in the guinea pig, tested the hypothesis that chronic maternal administration of antioxidant vitamins C plus E, together with ethanol, mitigates ethanol neurobehavioral teratogenicity. Pregnant guinea pigs received one of the following four chronic oral regimens: ethanol and vitamins C plus E; ethanol and vitamin vehicle; isocaloric-sucrose/pair-feeding and vitamins C plus E; or isocaloricsucrose/pair-feeding and vehicle. Vitamins C (250 mg) plus E (100 mg) or vehicle were given daily, and ethanol (4 g/kg maternal body weight/day) (E) or isocaloric-sucrose/pair-feeding was given for 5 consecutive days followed by 2 days of no treatment each week throughout gestation. One neonate from selected litters was studied on postnatal day (PD) 0. Neurobehavioral function was determined by measuring task acquisition and task retention using an 8-day moving-platform version of the Morris water-maze task, starting on PD 45. Thereafter, in vivo electrophysiologic assessment of changes in hippocampal synaptic plasticity was conducted. There was an et

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Author

Christopher M. Nash; Ferda Ibram; Hans C. Dringenberg; James N. Reynolds; James F. Brien

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2007

Language

EN

Field

Medicine (Health Sciences)