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Validation and implementation of the Panbio COVID-19 Ag rapid test for the diagnosis of SARS-CoV-2 infection in symptomatic hospital healthcare workers by Kolwijck, E. (author);Brouwers-Boers, M. (author);Broertjes, J. (author);van Heeswijk, K. (author);Runderkamp, N. (author);Meijer, A. (author);Hermans, M.H.A. (author);Leenders, A.C.A.P. (author) is a Medicine article available to read on EtoBox.

What is Validation and implementation of the Panbio COVID-19 Ag rapid test for the diagnosis of SARS-CoV-2 infection in symptomatic hospital healthcare workers about?

## Summary ## Background RT-PCR is the current recommended laboratory method to diagnose SARS-CoV-2 in healthcare workers (HCW). As RT-PCR is not widely available and is time-consuming, it limits decision making on removal from and return to work of possibly contagious HCW. ## Aim In this study we evaluated the PanbioTM COVID-19 Ag rapid test (PanbioCAgRT) in 825 hospital HCW. ## Methods and finding This study consisted of two phases. In the validation phase, we tested hospital HCW with mild symptoms (three days or less) in parallel using the PanbioCAgRT and the RT-qPCR test. The PanbioCAgRT demonstrated 86.7% sensitivity, 100% specificity, 100% PPV and 98.5% NPV with regard to RT-qPCR. For HCW with PanbioCAgRT-/RT-qPCR+, the median Ct value was 30.9, whereas for the HCW with PanbioCAgRT+/RT-qPCR+ the median Ct value was 19.3 (__P__<0.001). In the second phase, we implemented an on-site antigen test-based strategy for symptomatic hospital HCW: HCW that tested positive with the PanbioCAgRT on-site were considered SARS-CoV-2 positive and were sent home. HCW that tested negative with the PanbioCAgRT on-site were allowed to work with PPE pending RT-qPCR test results from the laboratory

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Author
Kolwijck, E. (author);Brouwers-Boers, M. (author);Broertjes, J. (author);van Heeswijk, K. (author);Runderkamp, N. (author);Meijer, A. (author);Hermans, M.H.A. (author);Leenders, A.C.A.P. (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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