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Can I read Perinatal Exposure to Glyphosate-based Herbicides Impairs Progeny Health and Placental Angiogenesis by Disturbing Mitochondrial Function on EtoBox?
Perinatal Exposure to Glyphosate-based Herbicides Impairs Progeny Health and Placental Angiogenesis by Disturbing Mitochondrial Function by Guangdong Bai; Xu Jiang; Jianwei Qin; Yingbin Zou; Wentao Zhang; Teng Teng; Baoming Shi; Haoyang Sun is a Environmental Science article available to read on EtoBox.
What is Perinatal Exposure to Glyphosate-based Herbicides Impairs Progeny Health and Placental Angiogenesis by Disturbing Mitochondrial Function about?
Glyphosate-based herbicides (GBHs) are the most widely used pesticide worldwide and can provoke placental injury. However, whether and how GBHs damage angiogenesis in the placenta is not yet known. This work evaluated the safety of glyphosate on pregnant sows based on the limit level by governments and investigated the effects and mechanism of Low-GBHs (20 mg/kg) and High-GBHs (100 mg/kg) exposure on placental angiogenesis. Results showed that gestational exposure to GBHs decreased placental vessel density and cell multiplication by interfering with the expression of VEGFA, PLGF, VEGFr2 and Hand2 (indicators of angiogenesis), which may be in relation to oxidative stress-induced disorders of mitochondrial fission and fusion as well as the impaired function of the mitochondrial respiratory chain. Additionally, GBHs destroyed barrier function and nutrient transport in the placenta, and was accompanied by jejunum oxidative stress in newborn piglets. However, GBHs exposure had no significant differences on sow reproductive performance. As a natural antioxidant, betaine treatment protected placenta and newborn piglets against GBHs-induced damage. In conclusion, GBHs impaired placental an
Who reads Perinatal Exposure to Glyphosate-based Herbicides Impairs Progeny Health and Placental Angiogenesis by Disturbing Mitochondrial Function?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Guangdong Bai; Xu Jiang; Jianwei Qin; Yingbin Zou; Wentao Zhang; Teng Teng; Baoming Shi; Haoyang Sun
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Environmental Science (Physical Sciences)