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Can I read The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau on EtoBox?
The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau by Lin-Lin Shen; Noralyn B. Mañucat-Tan; Shi-Hao Gao; Wei-Wei Li; Fan Zeng; Chi Zhu; Jun Wang; Xian-Le Bu; Yu-Hui Liu; Chang-Yue Gao; Zhi-Qiang Xu; Larisa Bobrovskaya; Peng Lei; Jin-Tai Yu; Weihong Song; Hua-Dong Zhou; Xiu-Qing Yao; Xin-Fu Zhou; Yan-Jiang Wang is a Neuroscience article available to read on EtoBox.
What is The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau about?
Tau pathology is characterized as a form of frontotemporal lobar degeneration (FTLD) known as FTLD-tau. The underlying pathogenic mechanisms are not known and no therapeutic interventions are currently available. Here, we report that the neurotrophin receptor p75NTR plays a critical role in the pathogenesis of FTLD-tau. The expression of p75NTR and the precursor of nerve growth factor (proNGF) were increased in the brains of FTLD-tau patients and mice (P301L transgenic). ProNGF-induced tau phosphorylation via p75NTR in vitro, which was associated with the AKT/glycogen synthase kinase (GSK)3β pathway. Genetic reduction of p75NTR in P301L mice rescued the memory deficits, alleviated tau hyperphosphorylation and restored the activity of the AKT/GSK3β pathway. Treatment of the P301L mice with the soluble p75NTR extracellular domain (p75ECD-Fc), which can antagonize neurotoxic ligands of p75NTR, effectively improved memory behavior and suppressed tau pathology. This suggests that p75NTR plays a crucial role in tau paGSKthology and represents a potential druggable target for FTLD-tau and related tauopathies.
Who reads The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Lin-Lin Shen; Noralyn B. Mañucat-Tan; Shi-Hao Gao; Wei-Wei Li; Fan Zeng; Chi Zhu; Jun Wang; Xian-Le Bu; Yu-Hui Liu; Chang-Yue Gao; Zhi-Qiang Xu; Larisa Bobrovskaya; Peng Lei; Jin-Tai Yu; Weihong Song; Hua-Dong Zhou; Xiu-Qing Yao; Xin-Fu Zhou; Yan-Jiang Wang
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1359-4184)
- Published
- 2018
- Language
- EN
- Field
- Neuroscience (Life Sciences)