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This study presents a rapid method for quantifying 36 underivatized amino acids in plasma using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. The method effectively identifies amino acid metabolism defects in patients with inborn errors of metabolism (IEM) and overcomes limitations of traditional analysis techniques. Results demonstrated excellent separation and quantification of amino acids within an 18-minute timeframe, making it suitable for clinical diagnos

Author
nicholas gobo
Language
EN

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