About this document

Pediatric Proton Pump Inhibitors Review by Antonio Gamiño Garcia is a document available to read on EtoBox.

This document provides an overview of proton pump inhibitors (PPIs) in pediatrics. PPIs work by irreversibly binding to cysteine sites on the gastric H+/K+-ATPase enzyme, also called the proton pump, which is responsible for acid secretion in the stomach. Some PPIs bind to exposed cysteine sites and their binding can be reversed, while others like pantoprazole bind irreversibly. PPIs undergo metabolic clearance primarily by the CYP2C19 and CYP3A4 cytochrome P450 enzymes, which reach adult levels of activity

Author

Antonio Gamiño Garcia

Language

EN