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Antigen-presenting cell-derived signals determine expression levels of CD70 on‘qc primed T cells by S. M. A. LENS; P. A. BAARS; B. HOOIBRINK; M. H. J. VAN OERS; R. A. W. VAN LIER is a Immunology and Microbiology article available to read on EtoBox.

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Interaction between CD27 and its ligand CD70 provides a second signal for T‐cell proliferation and tumour necrosis factor‐__α__ (TNF‐__α__) production. Whereas CD27 is broadly expressed during T‐cell development, expression of CD70 __in vivo__ is restricted. To determine when CD27–CD70 interactions can occur in immune reactions, we here analysed the regulation of CD70 expression on activated T cells. Mitogenic stimulation of purified T cells with either immobilized CD3 monoclonal antibody (mAb) or a combination of CD2 mAb induces only low levels of CD70 membrane expression. Markedly, expression of the CD27‐ligand is strongly enhanced by antigen‐presenting cells (APC) and APC‐associated signals such as interleukin‐1__α__ (IL‐1__α__), IL‐12, TNF‐__α__ and CD28‐ligation. In contrast, T‐cell derived cytokines, such as IL‐4, counteract CD70 up‐regulation on activated T cells. Analysis of the small subset of circulating CD70^+^ T cells revealed that these cells have a primed phenotype as they express CD45RO and HLA‐DR antigens and are in high frequency able to secrete interferon‐__γ__ (IFN‐__γ__). We conclude that T–T interactions involving CD27 and CD70 are likely to occur relatively ea

Who reads Antigen-presenting cell-derived signals determine expression levels of CD70 on‘qc primed T cells?

Author

S. M. A. LENS; P. A. BAARS; B. HOOIBRINK; M. H. J. VAN OERS; R. A. W. VAN LIER

Publisher

Wiley

Published

1997

Language

EN

Field

Immunology and Microbiology (Life Sciences)