Can I read Synthesis Of Two New Heterocyclic Ring Systems: 2-aza-6-thia-10-azaspiro[4,5]decane-1,3,9-trione-7-ene-7-benzoyl And 2-aza-7-thia-11-azaspiro[5,5]undecane-1,3,10-trione-8-ene-8-benzoyl Derivatives on EtoBox?

Synthesis Of Two New Heterocyclic Ring Systems: 2-aza-6-thia-10-azaspiro[4,5]decane-1,3,9-trione-7-ene-7-benzoyl And 2-aza-7-thia-11-azaspiro[5,5]undecane-1,3,10-trione-8-ene-8-benzoyl Derivatives by Georgia Tsolomiti; Kyriaki Tsolomiti; Athanase Tsolomitis is a Chemistry article available to read on EtoBox.

What is Synthesis Of Two New Heterocyclic Ring Systems: 2-aza-6-thia-10-azaspiro[4,5]decane-1,3,9-trione-7-ene-7-benzoyl And 2-aza-7-thia-11-azaspiro[5,5]undecane-1,3,10-trione-8-ene-8-benzoyl Derivatives about?

The synthesis of two new type heterocyclic derivatives, 2-aza-6-thia-10azaspiro [4,5]dccanc-l,3,9-trione-7-ene-7-benzoyl and 2-aza-7-thia-ll-azaspiro[5,5]undecane-l,3,10-trione-8-ene-8-benzoyl, from 2,3-dihydro-l,3-thiazine-4-ones which in turn were obtained via a rearrangement reaction of 3(2H)-isothiazol-3-ones prepared from properly designed 3-benzoylpropionamides, is described. Azabicyclic and azaspiro nuclei, containing a spiro carbon atom had been only cursorily touched in the literature 1 ' 2 until five decades ago, then a large number of azaspirane derivatives were developed 3 . Some of these products have shown inhibitory effects on cancer cells in tissue culture and objective clinical effects in human cancer. At that time, the same research group also reported 4 the synthesis of azaspirodione and azaspirane derivatives with a wide range of useful activities according to biological and pharmacological studies; the most notable was the effect produced on the peripheral and central nervous system.

Who reads Synthesis Of Two New Heterocyclic Ring Systems: 2-aza-6-thia-10-azaspiro[4,5]decane-1,3,9-trione-7-ene-7-benzoyl And 2-aza-7-thia-11-azaspiro[5,5]undecane-1,3,10-trione-8-ene-8-benzoyl Derivatives?

Author

Georgia Tsolomiti; Kyriaki Tsolomiti; Athanase Tsolomitis

Publisher

Walter de Gruyter GmbH

Published

2008

Language

EN

Field

Chemistry (Physical Sciences)