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Blood proteins self-assembly, staphylococcal enterotoxins-interaction, antibacterial synergistic activities of biogenic carbon/FeSO~4~/Cu/CuO nanocomposites modified with three antibiotics by Mehran Alavi; Nasser Karimi is a Chemistry article available to read on EtoBox.

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## Introduction Nanocomposites based on copper, iron, and carbon materials are novel nanomaterials with both antibacterial and biocompatibility properties considerable to fight against multidrug-resistant bacteria. ## Methods In this study, phytogenic carbon/FeSO~4~/Cu/CuO nanocomposites modified by three antibiotics including tetracycline, amoxicillin, and penicillin were employed to hinder antibiotic resistant bacteria of __Escherichia coli__, __Staphylococcus aureus__, and __Pseudomonas aeruginosa__. Interaction of albumin and hemoglobin as major blood proteins with these nanocomposites were evaluated by SEM, FTIR, and AFM techniques. As in silico study, molecular docking properties of staphylococcal enterotoxin toxin A and B with (Z)-α-Bisabolene epoxide, (E)-Nerolidol, α-Cyperone, daphnauranol C, nootkatin, and nootkatone as major secondary metabolites of Daphne mucronata were obtained by AutoDock Vina program. ## Results Physicochemical characterization of nanocomposites showed (Zeta potential (− 5.09 mV), Z-average (460.2 d.nm), polydispersity index (0.293), and size range of 44.58 ± 6.78 nm). Results of both in vitro and in silico surveys disclosed significant antibacterial

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Author

Mehran Alavi; Nasser Karimi

Publisher

Springer

Published

2024

Language

EN

Field

Chemistry (Physical Sciences)