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Can I read Cyanidin-3-glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain on EtoBox?
Cyanidin-3-glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain by Zunji Ke; Ying Liu; Xin Wang; Zhiqin Fan; Gang Chen; Mei Xu; Kimberley A. Bower; Jacqueline A. Frank; Xiaoming Ou; Xianglin Shi; Jia Luo is a Neuroscience article available to read on EtoBox.
What is Cyanidin-3-glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain about?
Ethanol exposure induces neurodegeneration in the developing central nervous system (CNS). Fetal alcohol spectrum disorders (FASD) are caused by ethanol exposure during pregnancy and are the most common nonhereditary cause of mental retardation. It is important to identify agents that provide neuroprotection against ethanol neurotoxicity. Multiple mechanisms have been proposed for ethanol-induced neurodegeneration, and oxidative stress is one of the most important mechanisms. Recent evidence indicates that glycogen synthase kinase 3β (GSK3β) is a potential mediator of ethanol-mediated neuronal death. Cyanidin-3-glucoside (C3G), a member of the anthocyanin family, is a potent natural antioxidant. Our previous study suggested that C3G inhibited GSK3β activity in neurons. Using a third trimester equivalent mouse model of ethanol exposure, we tested the hypothesis that C3G can ameliorate ethanol-induced neuronal death in the developing brain. Intraperitoneal injection of C3G reduced ethanol-meditated caspase-3 activation, neurodegeneration, and microglial activation in the cerebral cortex of 7-day-old mice. C3G blocked ethanol-mediated GSK3β activation by inducing phosphorylation at se
Who reads Cyanidin-3-glucoside Ameliorates Ethanol Neurotoxicity in the Developing Brain?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Zunji Ke; Ying Liu; Xin Wang; Zhiqin Fan; Gang Chen; Mei Xu; Kimberley A. Bower; Jacqueline A. Frank; Xiaoming Ou; Xianglin Shi; Jia Luo
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2011
- Language
- EN
- Field
- Neuroscience (Life Sciences)