Can I read Characterization of Regions of Chromosomes 12 and 16 Involved in Nephroblastoma Tumorigenesis on EtoBox?

Characterization of Regions of Chromosomes 12 and 16 Involved in Nephroblastoma Tumorigenesis by Estelle Austruy; Sophie Candon; Isabelle Henry; Gabor Gyapay; Marie‐France Tournade; Marcel Mannens; David Callen; Claudine Junien; Cécile Jeanpierre is a Medicine article available to read on EtoBox.

What is Characterization of Regions of Chromosomes 12 and 16 Involved in Nephroblastoma Tumorigenesis about?

## Abstract There are at least three loci involved in Wilms' tumor (WT) tumorigenesis: __WT1__ in 11p13, __WT2__ in 11p15.5, and __WT3__, as yet unmapped. A compilation of cytogenetic data published for 107 WT revealed that deletion of chromosome 16 and duplication of chromosome 12 occur as frequently as the well‐documented 11p deletions. Allelic imbalance for chromosomes 16 and 12 was investigated in a series of 28 WT. By use of a large panel of restriction fragment length polymorphisms and (CA)n probes, we demonstrated loss of heterozygosity (LOH) for 16q in seven (25%) of the tumors. The whole length of 16q was involved in six of the tumors. Moreover, consistent with a previous report of 16q13 LOH in a sporadic WT and a constitutional breakpoint in a Beckwith‐Wiedemann patient, we map a region of particular interest to between D16S308 and D16S320. The assumption that 16q LOH may be an early event was based on: 1) the detection of 16q LOH in one case of nephroblastomatosis; 2) the presence of a complete (clonal) 16q LOH in a tumor with partial (mosaic) 11p LOH; and 3) 16q LOH as the sole abnormality in one WT. By quantification of chromosome 12 allelic imbalance, we detected dupl

Who reads Characterization of Regions of Chromosomes 12 and 16 Involved in Nephroblastoma Tumorigenesis?

Author

Estelle Austruy; Sophie Candon; Isabelle Henry; Gabor Gyapay; Marie‐France Tournade; Marcel Mannens; David Callen; Claudine Junien; Cécile Jeanpierre

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

1995

Language

EN

Field

Medicine (Life Sciences)