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Can I read Amide Bond Formation in Aqueous Solution: Direct Coupling of Metal Carboxylate Salts with Ammonium Salts at Room Temperature on EtoBox?
Amide Bond Formation in Aqueous Solution: Direct Coupling of Metal Carboxylate Salts with Ammonium Salts at Room Temperature by Truong Thanh Tung; John Nielsen is a Chemistry article available to read on EtoBox.
What is Amide Bond Formation in Aqueous Solution: Direct Coupling of Metal Carboxylate Salts with Ammonium Salts at Room Temperature about?
Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/HO conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales.
Who reads Amide Bond Formation in Aqueous Solution: Direct Coupling of Metal Carboxylate Salts with Ammonium Salts at Room Temperature?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Truong Thanh Tung; John Nielsen
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)