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Can I read Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11 on EtoBox?
Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11 by Wenjing Ye; Qian Wang; Li Zhao; Changcheng Wang; Dandan Zhang; Mengyu Zhou; Fangfang Chen; Weiguo Wang; Zaihua Zhu; Wenyu Guo; Yun Liu; Hejian Zou; Yu Xue is a Immunology and Microbiology article available to read on EtoBox.
What is Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11 about?
Objectives: Systemic sclerosis (SSc) is a rare rheumatic disease characterized by vascular damage, dysregulated immune response, and fibrosis. is upregulated in SSc. This study aimed to investigate the pathological and therapeutic role of the IL-11 transsignaling pathway in SSc. Methods: Plasma IL-11 level was evaluated in 32 patients with SSc and 15 healthy controls, while the expression levels of ADAM10, ADAM17, IL-11, IL-11 Rα, or IL-11 co-stained with CD3 or CD163 in the skin of SSc patients and healthy controls were analyzed. Fibroblasts were treated with IL-11 and ionomycin to evaluate the profibrotic effect of IL-11 trans-signaling pathway. TJ301 (sgp130Fc) and WP1066 (a JAK2/STAT3 inhibitor) intervention groups were set up to investigate the antifibrotic effect of targeting IL-11. Results: Levels of plasma IL-11 were extremely low in most SSc patients and healthy controls. In contrast, levels of IL-11, IL-11 Rα, and ADAM10, but not ADAM17, were significantly elevated in the skin of SSc patients. Moreover, the numbers of IL-11 + CD3 + cells and IL-11 + CD163 + cells were increased in the skin of SSc patients. Besides, IL-11 and ADAM10 were also elevated in the skin and pulmo
Who reads Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Wenjing Ye; Qian Wang; Li Zhao; Changcheng Wang; Dandan Zhang; Mengyu Zhou; Fangfang Chen; Weiguo Wang; Zaihua Zhu; Wenyu Guo; Yun Liu; Hejian Zou; Yu Xue
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)