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What is Nonlinear Pharmacokinetics Overview about?

Nonlinear pharmacokinetics occurs when the elimination of a drug does not follow first-order kinetics and the pharmacokinetic parameters such as elimination half-life change with increasing dose. Drugs that exhibit saturation kinetics show non-linear elimination that can be described by Michaelis-Menten kinetics. The elimination half-life and clearance are dependent on dose and plasma concentration for drugs that follow nonlinear kinetics. Mixed elimination pathways and time-dependent changes in absorption

Author

Mubashar Shahid

Language

EN