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Platelet and Hemocoagulative Changes in Elderly Atherosclerotic Patients After Treatment with the Antiaggregating Drug Picotamide by Giuseppe Aliberti; Maria Proietta; Isabella Pulignano is a Medicine article available to read on EtoBox.

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The effects of the antiaggregating drug picotamide on platelet and hemocoagulative parameters were evaluated in a group of 28 elderly atherosclerotic patients. After 1 month of treatment, consisting of one 300 mg tablet three times per day, a significant inhibition of platelet aggregability in response to ADP, adrenaline, arachidonic acid and collagen and a reduction of the mean platelet volume (-4.629 7.46%, PB 0.003) was observed. Fibrinogen plasma levels, unchanged at the 15th day, were significantly reduced at the 30th day, from 445.69145.95 to 382.729110.56 mg/dl (PB 0.01), while no changes were observed in antithrombin III, factor VII, D-dimer plasma levels and in plasmatic and urinary fibrin(ogen) degradation products values. The results seem to indicate a reduction after antiaggregating treatment of the interaction between the platelets and the vessel wall, that may be responsible for the changes observed.

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Author

Giuseppe Aliberti; Maria Proietta; Isabella Pulignano

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0167-4943)

Published

1997

Language

EN

Field

Medicine (Health Sciences)