Can I read ANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives on EtoBox?

ANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives by Austin, Keziah (author);Janagan, Shalini (author);Wells, Matthew (author);Crawshaw, Helena (author);McAdoo, Stephen (author);Robson, Joanna C (author) is a Medicine article available to read on EtoBox.

What is ANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives about?

## Abstract The ANCA associated vasculitides (AAVs) affect a range of internal organs including ear nose and throat, respiratory tract, kidneys, skin and nervous system. They include granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis (MPA). The AAVs are treated with high dose glucocorticoids, immunosuppressants, and targeted biological medications. Since the 1990s classification criteria for the AAVs have been based on clinical features, laboratory tests and basic imaging; an initiative to update the classification criteria incorporating newer tests, for example, anti-neutrophil cytoplasmic antibodies (ANCA) and novel imaging techniques will be published this year. There is also evidence for classification of patients based on ANCA subtype; those with anti-proteinase 3 antibodies (PR3) or anti-myeloperoxidase antibodies (MPO) have differences in response to treatment and clinical outcomes. An update is described within this review. The pathogenesis of AAV involves necrotizing inflammation of small to medium blood vessels involving multiple immunological pathways. We present an update on emerging evidence related

Who reads ANCA Associated Vasculitis Subtypes: Recent Insights and Future Perspectives?

Author

Austin, Keziah (author);Janagan, Shalini (author);Wells, Matthew (author);Crawshaw, Helena (author);McAdoo, Stephen (author);Robson, Joanna C (author)

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Medicine (Health Sciences)