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The study by Greer et al. investigates the role of histone deacetylases (HDACs) in regulating transcription elongation across the human genome, revealing that HDAC inhibitors (HDACIs) block elongation by affecting the binding of elongation factors and reducing enhancer RNA production. The research demonstrates that HDACs stimulate transcription elongation through mechanisms involving heat shock protein 90 (HSP90) and the eviction of negative elongation factor (NELF) at promoters. Overall, the findings sugge
- Author
- Itzel Mercado
- Language
- EN