Can I read Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-oxide Loaded Cells on EtoBox?

Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-oxide Loaded Cells by Chris V. Bowen; Xiaowei Zhang; George Saab; Paula J. Gareau; Brian K. Rutt is a Medicine article available to read on EtoBox.

What is Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-oxide Loaded Cells about?

The relaxation rates of iron-oxide nanoparticles compartmentalized within cells were studied and found to satisfy predictions of the static dephasing (SD) regime theory. THP-1 cells in cell culture were loaded using two different iron-oxide nanoparticles (superparamagnetic iron-oxide (SPIO) and ultrasmall SPIO (USPIO)) with four different iron concentrations (0.05, 0.1, 0.2, and 0.3 mg/ml) and for five different incubation times (6, 12, 24, 36, and 48 hr). Cellular iron-oxide uptake was assessed using a newly developed imaging version of MR susceptometry, and was found to be linear with both dose and incubation time. R(2)\* sensitivity to iron-oxide loaded cells was found to be 70 times greater than for R(2), and 3100 times greater than for R(1). This differs greatly from uniformly distributed nanoparticles and is consistent with a cellular bulk magnetic susceptibility (BMS) relaxation mechanism. The cellular magnetic moment was large enough that R(2)' relaxivity agreed closely with SD regime theory predictions for all cell samples tested [R(2)'=2 pi/(9 x the square root of 3) x gamma LMD] where the local magnetic dose (LMD) is the sample magnetization due to the presence of iron-o

Who reads Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-oxide Loaded Cells?

Author

Chris V. Bowen; Xiaowei Zhang; George Saab; Paula J. Gareau; Brian K. Rutt

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2002

Language

EN

Field

Medicine (Health Sciences)