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In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT2A receptors: effect of antipsychotic drugs by Analía Bortolozzi; Mercè Amargós-Bosch; Albert Adell; Llorenç Díaz-Mataix; Jordi Serrats; Sebastià Pons; Francesc Artigas is a scholarly article available to read on EtoBox.

What is In vivo modulation of 5-hydroxytryptamine release in mouse prefrontal cortex by local 5-HT2A receptors: effect of antipsychotic drugs about?

## Abstract In the rat, postsynaptic 5‐hydroxytryptamine~2A~ receptors medial prefrontal cortex control the activity of the serotonergic system through changes in the activity of pyramidal neurons projecting to the dorsal raphe nucleus. Here we extend these observations to mouse brain. The prefrontal cortex expresses abundant 5‐ hydroxytryptamine~2A~ receptors, as assessed by immunohistochemistry, Western blots and __in situ__ hybridization procedures. The application of the 5‐hydroxytryptamine~2A/2C~ agonist DOI (100 μm) by reverse dialysis in the medial prefrontal cortex doubled the local release of 5‐hydroxytryptamine. This effect was reversed by coperfusion of tetrodotoxin, and by the selective 5‐hydroxytryptamine~2A~ receptor antagonist M100907, but not by the 5‐hydroxytryptamine~2C~ antagonist SB‐242084. The effect of DOI was also reversed by prazosin (α~1~‐adrenoceptor antagonist), BAY × 3702 (5‐hydroxytryptamine~1A~ receptor agonist), NBQX (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐4‐propionate/kainic acid antagonist) and 1S,3S‐ACPD (mGluR II/III agonist), but not by dizocilpine (__N__‐methyl‐d‐aspartate antagonist). α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐4‐propionate mimicked

Author

Analía Bortolozzi; Mercè Amargós-Bosch; Albert Adell; Llorenç Díaz-Mataix; Jordi Serrats; Sebastià Pons; Francesc Artigas

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2003

Language

EN