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Can I read Macrophage Depletion in Stellate Ganglia Alleviates Cardiac Sympathetic Overactivation and Ventricular Arrhythmogenesis by Attenuating Neuroinflammation in Heart Failure on EtoBox?
Macrophage Depletion in Stellate Ganglia Alleviates Cardiac Sympathetic Overactivation and Ventricular Arrhythmogenesis by Attenuating Neuroinflammation in Heart Failure by Dongze Zhang; Wenfeng Hu; Huiyin Tu; Bryan T. Hackfort; Bin Duan; Wanfen Xiong; Michael C. Wadman; Yu-Long Li is a Medicine article available to read on EtoBox.
What is Macrophage Depletion in Stellate Ganglia Alleviates Cardiac Sympathetic Overactivation and Ventricular Arrhythmogenesis by Attenuating Neuroinflammation in Heart Failure about?
Cardiac sympathetic overactivation is involved in arrhythmogenesis in patients with chronic heart failure (CHF). Inflammatory infiltration in the stellate ganglion (SG) is a critical factor for cardiac sympathoexcitation in patients with ventricular arrhythmias. This study aims to investigate if macrophage depletion in SGs decreases cardiac sympathetic overactivation and ventricular arrhythmogenesis in CHF. Surgical ligation of the coronary artery was used for induction of CHF. Clodronate liposomes were microinjected into bilateral SGs of CHF rats for macrophage depletion. Using cytokine array, immunofluorescence staining, and Western blot analysis, we found that macrophage expansion and expression of TNFα and IL-1β in SGs were markedly increased in CHF rats. Flow cytometry data confirmed that the percentage of macrophages in SGs was higher in CHF rats than that in sham rats. Clodronate liposomes significantly reduced CHF-elevated proinflammatory cytokine levels and macrophage expansion in SGs. Clodronate liposomes also reduced CHF-increased N-type Ca^2+^ currents and excitability of cardiac sympathetic postganglionic neurons and inhibited CHF-enhanced cardiac sympathetic nerve act
Who reads Macrophage Depletion in Stellate Ganglia Alleviates Cardiac Sympathetic Overactivation and Ventricular Arrhythmogenesis by Attenuating Neuroinflammation in Heart Failure?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dongze Zhang; Wenfeng Hu; Huiyin Tu; Bryan T. Hackfort; Bin Duan; Wanfen Xiong; Michael C. Wadman; Yu-Long Li
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)