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Experimental amitriptyline poisoning: Treatment of severe cardiovascular toxicity with cardiopulmonary bypass by Gregory Luke Larkin; Geoffrey M. Graeber; Michael J. Hollingsed is a Medicine article available to read on EtoBox.

What is Experimental amitriptyline poisoning: Treatment of severe cardiovascular toxicity with cardiopulmonary bypass about?

## Study objective: To compare cardiopulmonary bypass (cpb) with more conventional therapy in the treatment of severe amitriptyline poisoning. ## Design: Prospective, randomized, controlled, laboratory investigation. ## Interventions: Profound cardiovascular toxicity was induced in 20 anesthetized yorkshire swine (72 +/- 8.3 kg) by amitriptyline infusion at 0.5 mg/kg/min. ventilation was adjusted to keep arterial ph at 7.50 +/- 0.05 and the pco2 at 35 mm hg. the swine were randomized in a 1:1 ratio to one of two groups, cpb or control. both groups received amitriptyline infusion until they experienced near-lethal toxicity, defined as a systolic blood pressure below 30 mm hg for one minute. the control group was then given supportive treatment, including iv fluids, sodium bicarbonate, vasopressors, and standard pharmacologic (advanced cardiac life support) interventions. control animals failing to respond to supportive measures after five minutes were given open-chest cardiac massage for 30 minutes or until the return of spontaneous circulation. the cpb group received only mechanical support by cpb for 90 to 120 minutes. no sodium bicarbonate, antiarrhythmics, or cardiotonic agents

Who reads Experimental amitriptyline poisoning: Treatment of severe cardiovascular toxicity with cardiopulmonary bypass?

Author

Gregory Luke Larkin; Geoffrey M. Graeber; Michael J. Hollingsed

Publisher

Elsevier Science; Elsevier ; Mosby Inc.; Elsevier BV (ISSN 1097-6760)

Published

1994

Language

EN

Field

Medicine (Health Sciences)