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Can I read HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China on EtoBox?
HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China by Wenhui Chang; Mengyan Zhang; Qiang Ren; Yangfan Zou; Lifang Dong; Hua Jia; Feng Liu is a Medicine article available to read on EtoBox.
What is HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China about?
HIV-1 genetic distribution and recombinant patterns are important in understanding the HIV epidemic among men who have sex with men (MSM). In this study, 83 HIV-positive MSM infections were confirmed at a sentinel surveillance site in Xi'an city, China in 2018. HIV-1 genotypes were determined by phylogenetic analyses of HIV-1 gag, pol and env gene fragments, including CRF07\_BC (51.8%), CRF01\_AE (30.1%), subtype B (3.6%), CRF55\_01B (3.6%), CRF104\_0107 (1.2%) and unique recombinant forms (URFs) (9.6%). Transmitted drug resistance mutations were detected in 2.4% (2/82) of HIV-infected MSM individuals. The phylogenetic analyses of near full-length genome (NFLG) of HIV-1 URFs were performed. A new circulating recombinant form (CRF), designated as CRF104\_0107, was found in three epidemiologically unlinked individuals in Shaanxi province, China. The CRF104\_0107 is composed of genomes CRF01\_AE and CRF07\_BC, with six recombinant breakpoints in the gag, pol, vif and vpr genes. This second-generation CRF has a breakpoint (HXB2 nt 3011) in common with CRF07\_BC. The emergence of novel CRF and multiple URFs reflected HIV-1 genetic complexity among the local key populations in Xi'an city
Who reads HIV-1 genetic diversity and recombinant forms among men who have sex with men at a sentinel surveillance site in Xi'an City, China?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wenhui Chang; Mengyan Zhang; Qiang Ren; Yangfan Zou; Lifang Dong; Hua Jia; Feng Liu
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)