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What is Tuberous Sclerosis and Kidney Disease Insights about?

This research letter discusses a clinicopathologic evaluation of seven patients with Tuberous Sclerosis Complex (TSC) who developed chronic kidney disease (CKD) without large renal lesions or prior interventions. The findings indicate an atypical form of TSC-associated tubulointerstitial nephritis characterized by significant interstitial fibrosis, tubular atrophy, and mTOR pathway activation. The study suggests that mTOR inhibitors may not be beneficial for TSC-associated CKD, highlighting the need for fur

Author

engkametuduan07

Language

EN