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Can I read Endosulfan Induces Cardiotoxicity Through Apoptosis via Unbalance of Pro-survival and Mitochondrial-mediated Apoptotic Pathways on EtoBox?
Endosulfan Induces Cardiotoxicity Through Apoptosis via Unbalance of Pro-survival and Mitochondrial-mediated Apoptotic Pathways by Jialiu Wei; Jianhui Liu; Lianshuang Zhang; Yupeng Zhu; Xiangyang Li; Guiqing Zhou; Yanzhi Zhao; Zhiwei Sun; Xianqing Zhou is a Environmental Science article available to read on EtoBox.
What is Endosulfan Induces Cardiotoxicity Through Apoptosis via Unbalance of Pro-survival and Mitochondrial-mediated Apoptotic Pathways about?
Although the associations between endosulfan and adverse cardiovascular health have been reported, the toxic effects and underlying mechanism of endosulfan on the heart are not well understood. In this study, we examined the cardiotoxicity induced by endosulfan using Wistar rats and human cardiomyocytes (AC16) cells. Wistar rats were divided into control group (received corn oil alone) and three concentrations of endosulfan groups (1, 5 and 10 mg/kg·bw) by gavage. The AC16 cells were treated with three various concentrations (0, 1.25, 5, and 20 μg/mL) of endosulfan. The results showed that endosulfan induced cytotoxicity through damaging myocardial structure, decreasing the viability of cardiomyocytes, and elevating the serum levels of cardiac troponin I, heart fatty acid binding protein, aspartate aminotransferase, and reactive oxygen species (p < 0.05). Moreover, measurement of mitochondrial function showed that endosulfan could significantly decrease adenosine triphosphate levels and cytochrome c oxidase IV expression in AC16 cells (p < 0.05). In addition, endosulfan obviously inhibited Bcl-2 expression, activated the expressions of cytochrome c/Caspase-9/Caspase-3 signaling pat
Who reads Endosulfan Induces Cardiotoxicity Through Apoptosis via Unbalance of Pro-survival and Mitochondrial-mediated Apoptotic Pathways?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jialiu Wei; Jianhui Liu; Lianshuang Zhang; Yupeng Zhu; Xiangyang Li; Guiqing Zhou; Yanzhi Zhao; Zhiwei Sun; Xianqing Zhou
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV; Publons (ISSN 0048-9697)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Physical Sciences)