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New cblA gene participates in regulation of cobalt-dependent transcription of nitrile hydratase genes in Rhodococcus rhodochrous by Konstantin V. Lavrov; Anna O. Shemyakina; Elena G. Grechishnikova; Andrey D. Novikov; Denis D. Derbikov; Tatyana I. Kalinina; Alexander S. Yanenko is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Rhodococcus strains are important biocatalysts used for biotechnological production of acrylamide catalysed by a nitrile hydratase (NHase) containing cobalt. This metalloenzyme is present at high intracellular concentrations representing up to 50% of the soluble proteins in Rhodococcus rhodochrous M8 strain. Cobalt ions were formerly reported to be essential for the synthesis of the NHase subunits, encoded by nhmBA structural genes in R. rhodochrous M8. To understand the regulatory mechanisms enabling high expression of the NHase structural genes by cobalt, two reporter genes coding for an acylamidase from Rhodococcus erythropolis TA37 and a nitrilase from Alcaligenes denitrificans C-32 were fused to the nhmBA promoter. It was shown that cobalt-dependent regulation of transcription occurs independently of another

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Author

Konstantin V. Lavrov; Anna O. Shemyakina; Elena G. Grechishnikova; Andrey D. Novikov; Denis D. Derbikov; Tatyana I. Kalinina; Alexander S. Yanenko

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0923-2508)

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)