Can I read Modulation of intraepithelial expansion of human T24 bladder‐carcinoma cells in murine urothelium by growth factors and extracellular‐matrix components on EtoBox?

Modulation of intraepithelial expansion of human T24 bladder‐carcinoma cells in murine urothelium by growth factors and extracellular‐matrix components by Johanna M. J. Rebel; Cornelia D. E. M. Thijssen; Marcel Vermey; Ellen C. Zwarthoff; Theodorus H. Van Der Kwast is a Medicine article available to read on EtoBox.

What is Modulation of intraepithelial expansion of human T24 bladder‐carcinoma cells in murine urothelium by growth factors and extracellular‐matrix components about?

## Abstract The high recurrence rate of bladder cancer is probably due to an efficient repopulation of the bladder by residual transformed cells after resection of the tumour. However, the regenerating capacity of the normal urothelial cells is very high. To study the balance between regenerating normal urothelium and outgrowth of transformed urothelial cells, we recently developed an __in vitro__ co‐cultivation model. With this model system we studied the effects of growth factors and extracellular‐matrix components on the intra‐epithelial expansion of human T24 bladder‐carcinoma cells in primary mouse‐bladder explants. Exposure of the cultures to acidic fibroblast growth factor (aFGF) and laminin led to a dramatic increase in the number of invasive T24 cells into the primary urothelium. Epidermal growth factor (EGF) and collagen types I and IV counteracted the infiltration of individual T24 cells. EGF, aFGF, laminin and collagen types I and IV did not directly affect the migration and proliferation of T24 cells. Apparently, the efficacy of invasion of transformed urothelial cells into primary urothelium is not only dependent on the intrinsic characteristics of the transformed cel

Who reads Modulation of intraepithelial expansion of human T24 bladder‐carcinoma cells in murine urothelium by growth factors and extracellular‐matrix components?

Author

Johanna M. J. Rebel; Cornelia D. E. M. Thijssen; Marcel Vermey; Ellen C. Zwarthoff; Theodorus H. Van Der Kwast

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1995

Language

EN

Field

Medicine (Health Sciences)