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Can I read Enzyme‐Triggered Chemodynamic Therapy via a Peptide‐H2S Donor Conjugate with Complexed Fe2+ on EtoBox?
Enzyme‐Triggered Chemodynamic Therapy via a Peptide‐H2S Donor Conjugate with Complexed Fe2+ by Yumeng Zhu; William R. Archer; Katlyn F. Morales; Michael D. Schulz; Yin Wang; John B. Matson is a Chemistry article available to read on EtoBox.
What is Enzyme‐Triggered Chemodynamic Therapy via a Peptide‐H2S Donor Conjugate with Complexed Fe2+ about?
Inducing high levels of reactive oxygen species (ROS) inside tumor cells is a cancer therapy method termed chemodynamic therapy (CDT). Relying on delivery of Fenton reaction promoters such as Fe 2 + , CDT takes advantage of overproduced ROS in the tumor microenvironment. We developed a peptide-H 2 S donor conjugate, complexed with Fe 2 + , termed AAN-PTC-Fe 2 + . The AAN tripeptide was specifically cleaved by legumain, an enzyme overexpressed in glioma cells, to release carbonyl sulfide (COS). Hydrolysis of COS by carbonic anhydrase formed H 2 S, an inhibitor of catalase, an enzyme that detoxifies H 2 O 2 . Fe 2 + and H 2 S together increased intracellular ROS levels and decreased viability in C6 glioma cells compared with controls lacking either Fe 2 + , the AAN sequence, or the ability to generate H 2 S. AAN-PTC-Fe 2 + performed better than temezolimide while exhibiting no cytotoxicity toward H9C2 cardiomyocytes. This study provides an H 2 Samplified, enzyme-responsive platform for synergistic cancer treatment.
Who reads Enzyme‐Triggered Chemodynamic Therapy via a Peptide‐H2S Donor Conjugate with Complexed Fe2+?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Yumeng Zhu; William R. Archer; Katlyn F. Morales; Michael D. Schulz; Yin Wang; John B. Matson
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)