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Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality by Jessica O’Loughlin; Francesco Casanova; Zammy Fairhurst-Hunter; Amanda Hughes; Jack Bowden; Edward R. Watkins; Rachel M. Freathy; Iona Y. Millwood; Kuang Lin; Zhengming Chen; Liming Li; Jun Lv; Robin G. Walters; Laura D. Howe; Karoline Kuchenbaecker; Jessica Tyrrell is a Medicine article available to read on EtoBox.

What is Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality about?

Abstract Background Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is limited. Here, we test the relationship between body composition and depression in people of East Asian ancestry. Methods Multiple Mendelian randomisation (MR) methods were used to test the relationship between (a) BMI and (b) waist-hip ratio (WHR) with depression. Firstly, we performed two-sample MR using genetic summary statistics from a recent genome-wide association study (GWAS) of depression (with 15,771 cases and 178,777 controls) in people of East Asian ancestry. We selected 838 single nucleotide polymorphisms (SNPs) correlated with BMI and 263 SNPs correlated with WHR as genetic instrumental variables to estimate the causal effect of BMI and WHR on depression using the inverse-variance weighted (IVW) method. We repeated these analyses stratifying by home location status: China versus UK or USA. Secondly, we performed one-sample MR in the China Kadoorie Biobank (CKB) in 100,377 participants. This allowed us to test the relationship separately in (a) mal

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Author

Jessica O’Loughlin; Francesco Casanova; Zammy Fairhurst-Hunter; Amanda Hughes; Jack Bowden; Edward R. Watkins; Rachel M. Freathy; Iona Y. Millwood; Kuang Lin; Zhengming Chen; Liming Li; Jun Lv; Robin G. Walters; Laura D. Howe; Karoline Kuchenbaecker; Jessica Tyrrell

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)