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Clinical Characteristics of Fibroblast Growth Factor Receptor 3 Antibody‐related Polyneuropathy: a Retrospective Study by S. Kovvuru; Y. C. Cardenas; A. Huttner; R. J. Nowak; B. Roy is a Medicine article available to read on EtoBox.
What is Clinical Characteristics of Fibroblast Growth Factor Receptor 3 Antibody‐related Polyneuropathy: a Retrospective Study about?
## Background and purpose Autoantibodies are increasingly being used as a diagnostic biomarker of chronic inflammatory neuropathies. However, their role and associated clinical syndrome are not well defined. ## Methods This retrospective chart review evaluated the clinical presentation, diagnostic workup and therapeutic responses in fibroblast growth factor receptor 3 (FGFR3) antibody‐associated neuropathy. ## Results A total of 27 patients [14 men, aged 29–87 (65 ± 14) years] with positive FGFR3 antibody were included. Distal lower‐extremity paresthesia (66%), unsteady gait (26%) and foot drop (11%) were common presenting symptoms. Symptom onset was acute in four (15%) cases. Distal lower‐extremity weakness (mild in eight and severe in three patients) was the most frequent motor finding. Decreased distal sensation to pinprick (59%) and loss of vibration sensation (37%) were observed. Titer of FGFR3 ranged between 3100 and 30 000 (normal < 3000) with a mean of 10 688 ± 7284. Apart from the occasional association of other neuropathy‐related autoantibodies, comprehensive neuropathy workup was otherwise unrevealing. Six patients had other autoimmune disease and seven patients had a hi
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- Author
- S. Kovvuru; Y. C. Cardenas; A. Huttner; R. J. Nowak; B. Roy
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1351-5101)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)