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Can I read Synthesis and Biological Evaluation of Novel Thiocolchicine–podophyllotoxin Conjugates on EtoBox?
Synthesis and Biological Evaluation of Novel Thiocolchicine–podophyllotoxin Conjugates by Daniele Passarella; Bruno Peretto; Raul Blasco y Yepes; Graziella Cappelletti; Daniele Cartelli; Cristina Ronchi; John Snaith; Gabriele Fontana; Bruno Danieli; Jurgen Borlak is a Chemistry article available to read on EtoBox.
What is Synthesis and Biological Evaluation of Novel Thiocolchicine–podophyllotoxin Conjugates about?
The synthesis and biological evaluation of 9 dimeric compounds obtained by condensation of thiocolchicine and/or podophyllotoxin with 6 different dicarboxylic acids is described. In particular, tubulin assembly assay and immunofluorescence analysis results are reported. The biological data highlighted three compounds as being more active than the others, having a marked ability to inhibit the polymerization of tubulin in vitro and causing significant disruption to the microtubule network in vivo. The spacer unit was found to have a significant effect on biological activity, reinforcing the importance of the design of conjugate compounds to create new biologically active molecules in which the spacer could be useful to improve the solubility and to modulate the efficacy of well known anticancer drugs.
Who reads Synthesis and Biological Evaluation of Novel Thiocolchicine–podophyllotoxin Conjugates?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Daniele Passarella; Bruno Peretto; Raul Blasco y Yepes; Graziella Cappelletti; Daniele Cartelli; Cristina Ronchi; John Snaith; Gabriele Fontana; Bruno Danieli; Jurgen Borlak
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)