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Can I read Systematic Identification of Cell-fate Regulatory Programs Using a Single-cell Atlas of Mouse Development on EtoBox?
Systematic Identification of Cell-fate Regulatory Programs Using a Single-cell Atlas of Mouse Development by Lijiang Fei; Haide Chen; Lifeng Ma; Weigao E; Renying Wang; Xing Fang; Ziming Zhou; Huiyu Sun; Jingjing Wang; Mengmeng Jiang; Xinru Wang; Chengxuan Yu; Yuqing Mei; Danmei Jia; Tingyue Zhang; Xiaoping Han; Guoji Guo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Systematic Identification of Cell-fate Regulatory Programs Using a Single-cell Atlas of Mouse Development about?
Waddington's epigenetic landscape is a metaphor frequently used to illustrate cell differentiation. Recent advances in single-cell genomics are altering our understanding of the Waddington landscape, yet the molecular mechanisms of cell-fate decisions remain poorly understood. We constructed a cell landscape of mouse lineage differentiation during development at the single-cell level and described both lineage-common and lineage-specific regulatory programs during cell-type maturation. We also found lineage-common regulatory programs that are broadly active during the development of invertebrates and vertebrates. In particular, we identified Xbp1 as an evolutionarily conserved regulator of cell-fate determinations across different species. We demonstrated that Xbp1 transcriptional regulation is important for the stabilization of the gene-regulatory networks for a wide range of mouse cell types. Our results offer genetic and molecular insights into cellular gene-regulatory programs and will serve as a basis for further advancing the understanding of cell-fate decisions.
Who reads Systematic Identification of Cell-fate Regulatory Programs Using a Single-cell Atlas of Mouse Development?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lijiang Fei; Haide Chen; Lifeng Ma; Weigao E; Renying Wang; Xing Fang; Ziming Zhou; Huiyu Sun; Jingjing Wang; Mengmeng Jiang; Xinru Wang; Chengxuan Yu; Yuqing Mei; Danmei Jia; Tingyue Zhang; Xiaoping Han; Guoji Guo
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)