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Alterations in Cellular Gene Expression Without Changes in Nuclear Matrix Protein Content by Jill Macoska; Carol N. Hoover; Kenneth J. Pienta is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Alterations in Cellular Gene Expression Without Changes in Nuclear Matrix Protein Content about?

Cell metabolism and function are modulated in part by cell and nuclear shape. Nuclear shape is controlled by the nuclear matrix, the RNA-protein skeleton of the nucleus, and its interactions with cytoskeletal systems such as intermediate filaments and actin microfilaments. The nuclear matrix plays an important role in cell function and gene expression because active genes are bound to the nuclear matrix whereas inactive genes are not. It is unknown, however, how genes move on and off the matrix, and whether these events require compositional protein changes, i.e., alterations in protein content of the nuclear matrix, or other, more subtle alterations and/or modifications. The purpose of this investigation was to begin to determine how nuclear matrix protein composition is related to gene expression. We demonstrate that gene expression can change without apparent changes in the protein composition of the nuclear matrix in MCFl OA breast epithelial cells.

Who reads Alterations in Cellular Gene Expression Without Changes in Nuclear Matrix Protein Content?

Author

Jill Macoska; Carol N. Hoover; Kenneth J. Pienta

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)