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Can I read Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia on EtoBox?
Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia by Ronan Kapetanovic; Gregory Jouvion; Catherine Fitting; Marianna Parlato; Charlène Blanchet; Michel Huerre; Jean-Marc Cavaillon; Minou Adib-Conquy is a Medicine article available to read on EtoBox.
What is Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia about?
Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted in intensive-care units, causing septicaemia or pneumonia. In this work, we investigated the role of NOD2 in S. aureus-induced pneumonia. We found that the absence of NOD2 affected weight loss and recovery speed. Nod2À/À mice showed a reduced lung inflammation in comparison to wild-type animals, with lower presence of cytokines in broncho-alveolar lavage fluids and reduced recruitment of neutrophils. Furthermore, histological analysis of the lungs revealed less severe lesions in Nod2À/À mice at day 2 and day 7 post-infection. In conclusion, we demonstrated that NOD2 is not a crucial receptor to fight S. aureus-induced pneumonia, but that it contributes to the inflammatory response in the lungs. Interestingly, the absence of NOD2 led to a lesser inflammation and was finally beneficial for the animal recovery.
Who reads Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ronan Kapetanovic; Gregory Jouvion; Catherine Fitting; Marianna Parlato; Charlène Blanchet; Michel Huerre; Jean-Marc Cavaillon; Minou Adib-Conquy
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Life Sciences)