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Prostate cancer segregation analyses using 4390 families from UK and Australian population-based studies by Robert J. MacInnis; Antonis C. Antoniou; Rosalind A. Eeles; Gianluca Severi; Michelle Guy; Lesley McGuffog; Amanda L. Hall; Lynne T. O'Brien; Rosemary A. Wilkinson; David P. Dearnaley; Audrey T. Ardern‐Jones; Alan Horwich; Vincent S. Khoo; Christopher C. Parker; Robert A. Huddart; Margaret R. McCredie; Charmaine Smith; Melissa C. Southey; Margaret P. Staples; Dallas R. English; John L. Hopper; Graham G. Giles; Douglas F. Easton is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Familial aggregation of prostate cancer is likely to be due to multiple susceptibility loci, perhaps acting in conjunction with shared lifestyle risk factors. Models that assume a single mode of inheritance may be unrealistic. We analyzed genetic models of susceptibility to prostate cancer using segregation analysis of occurrence in families ascertained through population‐based series totaling 4390 incident cases. We investigated major gene models (dominant, recessive, general, X‐linked), polygenic models, and mixed models of susceptibility using the pedigree analysis software MENDEL. The hypergeometric model was used to approximate polygenic inheritance. The best‐fitting model for the familial aggregation of prostate cancer was the mixed recessive model. The frequency of the susceptibility allele in the population was estimated to be 0.15 (95% confidence interval (CI) 0.11–0.20), with a relative risk for homozygote carriers of 94 (95% CI 46–192), and a polygenic standard deviation of 2.01 (95% CI 1.72–2.34). These analyses suggest that one or more genes having a strong recessively inherited effect on risk, as well as a number of genes with variants having small multipl

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Author

Robert J. MacInnis; Antonis C. Antoniou; Rosalind A. Eeles; Gianluca Severi; Michelle Guy; Lesley McGuffog; Amanda L. Hall; Lynne T. O'Brien; Rosemary A. Wilkinson; David P. Dearnaley; Audrey T. Ardern‐Jones; Alan Horwich; Vincent S. Khoo; Christopher C. Parker; Robert A. Huddart; Margaret R. McCredie; Charmaine Smith; Melissa C. Southey; Margaret P. Staples; Dallas R. English; John L. Hopper; Graham G. Giles; Douglas F. Easton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)