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Can I read Molecular Nature of Chromosome 5Q Loss in Colorectal Tumors and Desmoids from Patients with Familial Adenomatous Polyposis on EtoBox?
Molecular Nature of Chromosome 5Q Loss in Colorectal Tumors and Desmoids from Patients with Familial Adenomatous Polyposis by Mieko Okamoto; Chieko Sato; Yuko Kohno; Takeo Mori; Takeo Iwama; Akira Tonomura; Yoshio Miki; Joji Utsunomiya; Yusuke Nakamura; Ray White; Michiko Miyaki is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Molecular Nature of Chromosome 5Q Loss in Colorectal Tumors and Desmoids from Patients with Familial Adenomatous Polyposis about?
Familial adenomatous polyposis (FAP), which includes familial polyposis coli (FPC) and the Gardner syndrome (GS), is a genetically determined premalignant disease of the colon inherited by a locus (APC) mapping within 5q15-q22. To elucidate the role of 5q loss in FAP tumorigenesis, we analysed 51 colorectal tumors and seven desmoids from 19 cases of FPC and five GS patients, as well as 15 sporadic colon cancers. RFLP analysis revealed a high incidence of allelic deletion in hereditary colon cancers as well as in sporadic colon cancers with a peak at the APC locus. APC loss resulted primarily from interstitial deletion or mitotic recombination. Combined tumor and pedigree analysis in a GS family revealed loss of normal 5q alleles in three tumors, including a desmoid tumor, which suggests the involvement of hemizygosity or homozygosity of the defective APC gene in colon carcinogenesis and, possibly, in extracolonic neoplasms associated with FAP.
Who reads Molecular Nature of Chromosome 5Q Loss in Colorectal Tumors and Desmoids from Patients with Familial Adenomatous Polyposis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mieko Okamoto; Chieko Sato; Yuko Kohno; Takeo Mori; Takeo Iwama; Akira Tonomura; Yoshio Miki; Joji Utsunomiya; Yusuke Nakamura; Ray White; Michiko Miyaki
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-6717)
- Published
- 1990
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)