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In Vitro Efficacy of Silk Sericin Microparticles and Platelet Lysate for Intervertebral Disk Regeneration by Elia Bari; Sara Perteghella; Giorgio Marrubini; Milena Sorrenti; Laura Catenacci; Giuseppe Tripodo; Maddalena Mastrogiacomo; Delia Mandracchia; Adriana Trapani; Silvio Faragò; Paolo Gaetani; Maria Luisa Torre is a Materials Science article available to read on EtoBox.
What is In Vitro Efficacy of Silk Sericin Microparticles and Platelet Lysate for Intervertebral Disk Regeneration about?
Intervertebral disk degeneration is an oxidative and inflammatory pathological condition that induces viability and functionality reduction of Nucleus Pulposus cells (NPs). Cellular therapies were previously proposed to repair and substitute the herniated disk but low proliferative index and pathological conditions of NPs dramatically reduced the efficacy of this approach. To overcome these problems we proposed, for the first time, a therapeutic system based on the association of silk sericin microparticles and platelet-derived products. Silk sericin (SS) is a bioactive protein with marked antioxidant properties, while platelet lysate (PL) and platelet poor plasma (PPP) represent a source of growth factors able to support cell viability and to promote tissue regeneration. We demonstrated that the mixture PL + PPP promoted NPs proliferation with a significant reduction of cellular doubling time. SS microparticles, alone or in combination with PPP, presented the higher ROS-scavenging activity while, SS microparticles and PL resulted as the best association able to protect NPs against oxidative stress induce by hydroxide peroxide. Based on these results, the authors are confident that
Who reads In Vitro Efficacy of Silk Sericin Microparticles and Platelet Lysate for Intervertebral Disk Regeneration?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Elia Bari; Sara Perteghella; Giorgio Marrubini; Milena Sorrenti; Laura Catenacci; Giuseppe Tripodo; Maddalena Mastrogiacomo; Delia Mandracchia; Adriana Trapani; Silvio Faragò; Paolo Gaetani; Maria Luisa Torre
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0141-8130)
- Published
- 2018
- Language
- EN
- Field
- Materials Science (Physical Sciences)