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What is Microwave Synthesis of Sulfonamides about?
This document describes a simple and efficient microwave-assisted method for synthesizing sulfonamides directly from sulfonic acids or their sodium salts. The key steps are: 1) React sulfonic acid with triethylamine and 2,4,6-trichloro-1,3,5-triazine in acetone under microwave irradiation. 2) Isolate the sulfonyl triazine intermediate and react it with various primary or secondary amines to yield the sulfonamide product. 3) This method produces sulfonamides in high yields (up to 95%) with good function
- Author
- Virender Kumar
- Language
- EN