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AURKA Gene Variants rs1047972, and rs8173 Are Associated With Breast Cancer by Eric Jonathan Maciel-Cruz; Luis Eduardo Figuera-Villanueva; Asbiel Felipe Garibaldi-Ríos; Belinda Claudia Gómez-Meda; Guillermo Moisés Zúñiga-González; Ana María Pérez; Paola B Castro-García; Ramiro Ramírez-Patiño; Martha Patricia Gallegos-Arreola is a Medicine article available to read on EtoBox.

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## Purpose Association between variants rs1047972 and rs8173 of the __AURKA__ gene in healthy women and breast cancer (BC) in a Mexican population. ## Methods Genomic DNA samples from 409 healthy women and 572 patients with BC were analyzed for variants rs1047972 and rs8173 of the __AURKA__ gene by polymerase chain reaction-restriction fragment length polymorphism. ## Results TT genotype (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.22–5.11; __p__ = 0.0015) and the T allele (OR, 1.16; 95% CI, 1.23–2.12; __p__ = 0.0007) of the rs1047972 variant were associated as risk susceptibility for BC relative to the control group. Contrarily, the GG genotype (OR, 0.64; 95% CI, 0.43–0.94; __p__ = 0.029) was associated as a protective factor of susceptibility of BC of the variant rs8173 of the __AURKA__ gene. Differences were observed in the patients with BC who were carriers of the CT genotype of the rs1047972 variant with overweight, obesity, estrogen receptor-positive plus obesity, Ki-67 (≥ 20%) plus history familial positive of cancer; and for variant rs8173 the BC patients who were CG carriers and presented chemotherapy gastric toxicity, hormonal receptor positive plus chemotherapy

Who reads AURKA Gene Variants rs1047972, and rs8173 Are Associated With Breast Cancer?

Author

Eric Jonathan Maciel-Cruz; Luis Eduardo Figuera-Villanueva; Asbiel Felipe Garibaldi-Ríos; Belinda Claudia Gómez-Meda; Guillermo Moisés Zúñiga-González; Ana María Pérez; Paola B Castro-García; Ramiro Ramírez-Patiño; Martha Patricia Gallegos-Arreola

Publisher

XMLink

Published

2023

Language

EN

Field

Medicine (Health Sciences)