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Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review by Ruby M. van Stein; Arend G. J. Aalbers; Gabe S. Sonke; Willemien J. van Driel is a Medicine article available to read on EtoBox.

What is Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review about?

etastatic spread to the peritoneum is a severe complication of cancer that causes debilitating symptoms and clinical deterioration and carries a poor prognosis. 1 Until the early 1990s, treatment of peritoneal metastases consisted of systemic chemotherapy and/or palliative surgery. 2 During the last 3 decades, however, increasing evidence supports the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to this multimodality approach. 3 HIPEC is a single intraoperative procedure that directly delivers chemotherapy in a heated solution to the abdominal cavity after cytoreductive surgery (CRS). After the first successful use in the treatment of pseudomyxoma peritonei in 1980 by Spratt and coworkers, 4 HIPEC has been explored in patients with peritoneal metastases originating from mesothelioma and gastric, ovarian, and colorectal cancer. This review describes the current knowledge regarding the mechanism of action, safety, and efficacy of HIPEC in the treatment of peritoneal metastases from epithelial ovarian and colorectal cancer and explores current knowledge gaps. Mechanism of Action ## Intraperitoneal Administration of Chemotherapy The use of intraperitoneal administratio

Who reads Hyperthermic Intraperitoneal Chemotherapy for Ovarian and Colorectal Cancer: A Review?

Author

Ruby M. van Stein; Arend G. J. Aalbers; Gabe S. Sonke; Willemien J. van Driel

Publisher

American Medical Association (AMA)

Published

2021

Language

EN

Field

Medicine (Health Sciences)