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A revised electronic version of RUCAM for the diagnosis of DILI by Paul H. Hayashi; M. Isabel Lucena; Robert J. Fontana; Einar S. Bjornsson; Guruprasad P. Aithal; Huiman Barnhart; Andres Gonzalez‐Jimenez; Qinghong Yang; Jiezhun Gu; Raul J. Andrade; Jay H. Hoofnagle is a Medicine article available to read on EtoBox.
What is A revised electronic version of RUCAM for the diagnosis of DILI about?
## Background and aims: Roussel uclaf causality assessment method (rucam) for dili has been hindered by subjectivity and poor reliability. we sought to improve the rucam using data from the drug-induced liver injury network (dilin) and the spanish dili registry, published literature, and iterative computer modeling. ## Approach and results: Rucam criteria were updated, clarified, and computerized. we removed criteria 3 (risk factors) for lack of added value and criteria 4 because we felt it more useful to assess each drug separately. criteria 6 (drug-specific risk) was anchored to livertox likelihood scores. iterative testing in subsets of 50-100 single-agent, nonherbal cases from both registries was done to optimize performance. we used classification tree analysis to establish diagnostic cutoffs for this revised electronic causality assessment method (recam) and compared recam with rucam for correlation with expert opinion diagnostic categories in 194 dili cases (98 dilin, 96 spanish dili). area under receiver operator curves for identifying at least probable dili were the same at 0.89 for recam and rucam. however, recam diagnostic categories have better observed overall agreemen
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- Author
- Paul H. Hayashi; M. Isabel Lucena; Robert J. Fontana; Einar S. Bjornsson; Guruprasad P. Aithal; Huiman Barnhart; Andres Gonzalez‐Jimenez; Qinghong Yang; Jiezhun Gu; Raul J. Andrade; Jay H. Hoofnagle
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)